Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

Abstract Background The pathophysiological mechanisms underlying multiple sclerosis include both inflammatory and degenerative processes. We aimed to study compare markers of neuroinflammation neurodegeneration in patients with first presentation demyelinating disorder prospectively identify which the studied serve as predictors for early conversion sclerosis. Thus, 42 clinical manifestations suggestive disease were included a prospective study. Subjects underwent thorough history taking evaluation. Laboratory studies involved analysis cerebrospinal fluid (CSF) serum chitinase 3-like 1 levels. Brain imaging MRI ultrasonographic assessment. Results T1 black holes, elevated oligoclonal bands (OCB), high baseline T2 lesion load, enhanced lesions significantly higher 1st attack Significantly CSF-OCB protein was detected (MS) compared clinically isolated syndrome, levels MS convertors than non-convertors. Cognitive dysfunction evaluated by MoCA test brain atrophy assessed using transcranial sonography did not show significant difference among groups. Logistic regression showed that heavy load served only predictor MS. Conclusion Early after demyelination is related detection signs rather neurodegeneration.